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January 23, 2026Journal of Crohn s and Colitis

P0876The efficacy of biologics and small molecules in the induction of remission in ulcerative proctitis: an international multicentre study

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Authors

FDF D’AmicoFFF FanizziSHS Honap

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Overview

International multicenter study evaluates advanced therapies effectiveness in achieving remission in ulcerative proctitis, suggesting promising real-world outcomes.

Key Points

  • This study aims to assess the effectiveness and safety of biologics and small molecules in inducing remission in patients with ulcerative proctitis.
  • International, multicenter, retrospective cohort design
  • Included adults with moderately to severely active ulcerative proctitis
  • Evaluated treatment with advanced therapies between 2000 and 2025
  • Primary outcome: steroid-free clinical remission (SF-CR) at week 12
  • Secondary outcomes included changes in bowel urgency, C-reactive protein, fecal calprotectin, and endoscopic scores.
  • Overall, 59.6% of patients achieved SF-CR at week 12
  • Significant reduction in Partial Mayo Score observed (p < 0.001)
  • Bowel urgency improved significantly (p < 0.001)
  • Both fecal calprotectin and C-reactive protein levels decreased significantly (both p < 0.001)
  • Endoscopic activity improved significantly with reductions in Mayo endoscopic score (p < 0.01) and Nancy score (p < 0.01)

Cite This Study

D’Amico et al. (2026) studied this question.

synapsesocial.com/papers/697310b0c8125b09b0d20587https://doi.org/10.1093/ecco-jcc/jjaf231.1057
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