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January 23, 2026Journal of Crohn s and Colitis

P0921Paradoxical dermatological manifestations under anti-tnf therapy in patients with Inflammatory Bowel Disease

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Authors

IEI ElbasriNLN LagdaliSSS Sabbah

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Overview

Retrospective study assesses paradoxical skin reactions under anti-TNF therapy in IBD patients, indicating a need for collaboration.

Key Points

  • The study aimed to evaluate the frequency and characteristics of paradoxical dermatological manifestations in IBD patients receiving anti-TNF therapy.
  • Retrospective analysis of 1,806 IBD patients from a single center
  • Assessment of clinical data and skin lesions related to anti-TNF therapy
  • Statistical analyses using chi-square and Student’s t tests
  • 15 patients (6.1%) developed paradoxical dermatological manifestations
  • Most frequent presentation was psoriasis (9 cases; 3.7%)
  • No significant associations with anti-TNF type, IBD phenotype, or patient age were found

Cite This Study

Elbasri et al. (2026) studied this question.

synapsesocial.com/papers/697310b0c8125b09b0d20690https://doi.org/10.1093/ecco-jcc/jjaf231.1102
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P0673Higher serum IL-23 levels associated with development of dermatological complications of anti-TNF therapy in Crohn’s Disease2026
  2. 2Anti-tumor necrosis factor-α therapy and paradoxical autoimmunity in inflammatory bowel disease: a need for risk-aware monitoring2026
  3. 3P0825Influence of extra-intestinal manifestations on disease severity and therapeutic response to anti-TNFα agents in Inflammatory Bowel Disease: A single-center retrospective study2026
  4. 4P0332Unmasking a Hidden Foe: Miliary Tuberculosis in a Young Crohn’s Patient during Anti-TNF Therapy2026
  5. 5Paradoxical Amicrobial Pustulosis of the Folds Induced by Tumor Necrosis Factor Inhibitor2026