Severe tricuspid regurgitation, defined by VCavg > 6 mm, EROA > 0.30 cm², RegVol > 30 mL, and RegFr > 45%, was associated with an event-free rate of only 14%.
Do quantitative echocardiographic parameters of tricuspid regurgitation severity predict the composite outcome of death and heart failure hospitalization in patients with at least mild TR?
Quantitative echocardiographic parameters provide prognostically meaningful thresholds to grade functional tricuspid regurgitation severity, with severe TR strongly predicting death and heart failure hospitalization.
Absolute Event Rate: 0% vs 0%
Abstract Aims Quantitative echocardiography parameters are seldom used to grade tricuspid regurgitation (TR) severity due to relative paucity of validation studies and lack of prognostic data. To assess the relationship between TR severity and the composite endpoint of death and hospitalization for congestive heart failure (CHF); and to identify the threshold values of vena contracta width (VCavg), effective regurgitant orifice area (EROA), regurgitant volume (RegVol), and regurgitant fraction (RegFr) to define low, intermediate, and high-risk TR based on patients’ outcome data. Methods and results A cohort of 296 patients with at least mild TR underwent 2D, 3D, and Doppler echocardiography. We built statistical models (adjusted for age, NYHA class, left ventricular ejection fraction, and pulmonary artery systolic pressure) for VCavg, EROA, RegVol, and RegFr to study their relationships with the hazard of outcome. The tertiles of the derived hazard values defined the threshold values of the quantitative parameters for TR severity grading. During 47-month follow-up, 32 deaths and 72 CHF occurred. Event-free rate was 14%, 48%, and 93% in patients with severe, moderate, and mild TR, respectively. Severe TR was graded as VCavg 6 mm, EROA 0.30 cm2, RegVol 30 mL, and RegF 45%. Conclusion This outcome study demonstrates the prognostic value of quantitative parameters of TR severity and provides prognostically meaningful threshold values to grade TR severity in low, intermediate, and high risk.
Muraru et al. (Tue,) reported a other. Severe tricuspid regurgitation, defined by VCavg > 6 mm, EROA > 0.30 cm², RegVol > 30 mL, and RegFr > 45%, was associated with an event-free rate of only 14%.
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