What question did this study set out to answer?

To review the clinical and discovery utility of mass spectrometry–based steroid metabolome analysis in diagnosing and managing adrenal steroidogenesis disorders and adrenal tumors.

July 11, 2019Endocrine ReviewsOpen Access

Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism

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Authors

KSKarl‐Heinz StorbeckStellenbosch University LSLina SchifferSylvester Comprehensive Cancer Center EBElizabeth S. BaranowskiBirmingham City University

Discussion

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Implication

Review demonstrates clinical utility of mass spectrometry steroid profiling in adrenal disorders, highlighting personalized diagnosis and tumor classification.

Key Points

To review the clinical and discovery utility of mass spectrometry–based steroid metabolome analysis in diagnosing and managing adrenal steroidogenesis disorders and adrenal tumors.
Reviewed serum and 24-hour urine steroid metabolome analysis using mass spectrometry methodologies.
Assessed integration of high-throughput multisteroid profiling with machine learning algorithms for clinical translation.
Steroid metabolome profiling reveals distinct multisteroid signatures that facilitate personalized diagnosis, differential diagnosis, and prognostic prediction of adrenal conditions.
Coupling mass spectrometry steroid measurement with machine learning enhances detection of inborn steroidogenic disorders and autonomous steroid secretion in adrenal tumors.

Cite This Study

Storbeck et al. (2019) studied this question.

synapsesocial.com/papers/6973844a5050f38cfa0dbed6 https://doi.org/10.1210/er.2018-00262

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Implication

Review demonstrates clinical utility of mass spectrometry steroid profiling in adrenal disorders, highlighting personalized diagnosis and tumor classification.

Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism

Discussion

Member takes

Implication

Key Points

Cite This Study

Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism

Discussion

Member takes

Implication

Key Points

Cite This Study

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