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A two-step synthesis demonstrates efficient generation of complex heterocyclic compounds, indicating potential in drug development.
The synthesis of substituted tetrahydroisoquinolinoquinolines via a two-step route involving a Pd-catalyzed N-arylation reaction followed by a Pd-catalyzed alkene carboamination reaction is described. The combined transformations lead to the generation of two rings and three bonds (two C–N and one C–C) and the heterocyclic products are obtained in moderate to good yields.
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Berges et al. (2026) studied this question.
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