Synthesis of Tetrahydroisoquinolinoquinolines via Sequential Pd-Catalyzed N-Arylation and Pd-Catalyzed Alkene Carboamination Reactions

Key Points

• The research aims to synthesize substituted tetrahydroisoquinolinoquinolines through a sequential reaction process.
• Conducted a two-step reaction involving Pd-catalyzed N-arylation followed by Pd-catalyzed alkene carboamination.
• Synthesized complex heterocyclic compounds by forming two C–N bonds and one C–C bond.
• Evaluated yields of the resulting products.
• The synthesis produced heterocyclic compounds in moderate to good yields.
• Both reactions successfully generated the expected ring systems and bonds.