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This method demonstrates the direct coupling of N-alkyl arylamines with alkenes, highlighting borane catalyst utility.
Tetrahydroquinolines are featured in molecules with wide ranging properties, including those with biological activity and materials applications. This report demonstrates that widely accessible N-alkyl arylamines can be directly coupled with new classes of alkenes to synthesize tetrahydroquinolines. The reaction is facilitated by a commercially available borane catalyst and enables the creation of novel tetrahydroquinoline scaffolds.
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Gloria et al. (2025) studied this question.
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