The aim is to explore the mechanisms of nephrotoxicity associated with triptolide using a liver-kidney interaction chip.
Developed a high-throughput liver-kidney organ-on-a-chip system
Integrated liver metabolism into nephrotoxicity studies
Utilized various metabolic assays to analyze drug interactions
Showed enhanced understanding of triptolide-induced nephrotoxicity
Revealed significant metabolic interactions between liver and kidney
Demonstrated the potential of liver-kidney chips for drug safety assessments
Abstract
The kidney organ-on-a-chip (OoC) is a powerful tool for studying drug-induced nephrotoxicity, but its application is limited by the absence of liver metabolism and low throughput. Here, we developed a...