What question did this study set out to answer?

To investigate how organ interactions affect drug safety, particularly in the context of drug-induced liver injury (DILI).

March 28, 2026Lab on a Chip

Gut-liver-on-a-chip Enables Mechanistic Study and Risk Assessment of Drug-Induced Liver Injury and Drug-Drug Interactions

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To investigate how organ interactions affect drug safety, particularly in the context of drug-induced liver injury (DILI).
Developed a pump-less gut-liver-on-chip model.
Assessed drug toxicity and drug-drug interactions.
Examined organ-level interactions relevant to drug safety.
Demonstrated enhanced mechanistic understanding of drug toxicity.
Identified key risk factors for drug-drug interactions related to liver injury.
Provided a platform for improved assessment of drug safety.

Implication

Reveals the risk factors of drug-induced liver injury using a novel gut-liver-on-chip model, indicating improved drug safety assessments.

Abstract

Current preclinical models face challenges in recapitulating organ-level interactions affecting drug safety and there has been little investigation into drug toxicity and related DILI. We presented a pump-less gut-liver-on-chip enabling...

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Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/69c771f08bbfbc51511e2187 https://doi.org/10.1039/d5lc01094b

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Implication

Reveals the risk factors of drug-induced liver injury using a novel gut-liver-on-chip model, indicating improved drug safety assessments.

Gut-liver-on-a-chip Enables Mechanistic Study and Risk Assessment of Drug-Induced Liver Injury and Drug-Drug Interactions

Key Points

Implication

Abstract

Discussion

Cite This Study

Gut-liver-on-a-chip Enables Mechanistic Study and Risk Assessment of Drug-Induced Liver Injury and Drug-Drug Interactions

Key Points

Implication

Abstract

Discussion

Cite This Study

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