Gut-liver-on-a-chip Enables Mechanistic Study and Risk Assessment of Drug-Induced Liver Injury and Drug-Drug Interactions

Key Points

• To investigate how organ interactions affect drug safety, particularly in the context of drug-induced liver injury (DILI).
• Developed a pump-less gut-liver-on-chip model.
• Assessed drug toxicity and drug-drug interactions.
• Examined organ-level interactions relevant to drug safety.
• Demonstrated enhanced mechanistic understanding of drug toxicity.
• Identified key risk factors for drug-drug interactions related to liver injury.
• Provided a platform for improved assessment of drug safety.