ABSTRACT A visible‐light‐driven radical phosphinylation of alkynes under neutral conditions has been developed. This metal‐free, redox‐neutral protocol enables divergent synthesis, as alkyl alkynes afford 1,2‐bisphosphonoethanes, whereas aryl, heteroaryl, or sterically hindered alkynes yield vinylphosphine oxides. The reaction exhibits excellent functional group tolerance and high regioselectivity, providing a green and practical route to valuable bisphosphonates and vinylphosphine oxides without requiring strong bases or transition‐metal catalysts. Mechanistic studies indicate a radical pathway initiated by visible‐light photolysis.
Dang et al. (Thu,) studied this question.