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Copper-catalyzed azodicarboxylate-alkyne (3+2) cycloaddition | Synapse

January 24, 2026Organic Chemistry Frontiers0 citations

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Copper-catalyzed azodicarboxylate-alkyne (3+2) cycloaddition

JLJian LeiQuanzhou Normal University JZJiayu ZhaoQuanzhou Normal University JGJiangbin GuoQuanzhou Normal University

Key Points

To develop a new regioselective (3+2) cycloaddition method for synthesizing N-aminooxazol-2-one scaffolds.
Utilized terminal alkynes and di-tert butyl azodicarboxylate under catalytic conditions.
Employed in situ-generated copper as the catalyst.
Focused on a regioselective reaction mechanism.
Successfully synthesized novel N-aminooxazol-2-one scaffolds.
Confirmed the efficiency of the cycloaddition reaction with high regioselectivity.

Abstract

A regioselective (3+2) cycloaddition between terminal alkynes and di-tert butyl azodicarboxylate under catalytic conditions is reported for the synthesis of novel N-aminooxazol-2-one scaffolds. The reaction employs an in situ-generated copper...

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Cite This Study

Lei et al. (Thu,) studied this question.

synapsesocial.com/papers/69746090bb9d90c67120a6ac https://doi.org/https://doi.org/10.1039/d5qo01596k