Copper-Catalyzed Enantioselective Interrupted Azide-Alkyne Cycloaddition to Access Axially Chiral Diaryl Ethers

Key Points

• This research aims to develop a method for synthesizing chiral 1,4,5-trisubstituted triazoles using copper-catalyzed processes.
• Utilized copper catalysis for azide-alkyne cycloaddition.
• Focused on enantioselective synthesis of diaryl ethers.
• Investigated the interrupted cycloaddition process.
• Achieved significant yields of chiral diaryl ethers.
• Notable enantioselectivity was observed in the synthesis.
• Expanded the scope of existing azide-alkyne cycloaddition methods.