Microfluidic capillary transit velocity as a functional measure for sickle cell disease and in vitro-derived red blood cells

Key Points

• This research aims to evaluate microfluidic capillary transit velocity as a measure of red blood cell function in sickle cell disease.
• Utilized microfluidic technology to measure capillary transit velocities of red blood cells.
• Compared transit velocities of in vitro-derived red blood cells and those from sickle cell patients.
• Assessed cellular responses to identify different functional abilities of red blood cells.
• Capillary transit velocity provides a functional measure of red blood cells in sickle cell disease.
• Significant differences in transit velocities were observed between healthy and sickle red blood cells.
• Microfluidic measurements revealed heterogeneity in responses among sickle cell patients.