Microfluidic capillary transit velocity as a functional measure for sickle cell disease and in vitro-derived red blood cells

Solomon Oshabaheebwa; Utku Goreke; Yong Du; Christopher L. Wirth; Zoe Sekyonda; Bryan L. Benson; Payam Fadaei; Yusang B. Ley; Nathan M Perez; Petros Giannikopoulos; David Nguyen; Michael A. Suster; Pedram Mohseni; Umut A. Gürkan

doi:10.1039/d5lc00769k

January 1, 2026Lab on a ChipOpen Access

Microfluidic capillary transit velocity as a functional measure for sickle cell disease and in vitro-derived red blood cells

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Key Points

This research aims to evaluate microfluidic capillary transit velocity as a measure of red blood cell function in sickle cell disease.
Utilized microfluidic technology to measure capillary transit velocities of red blood cells.
Compared transit velocities of in vitro-derived red blood cells and those from sickle cell patients.
Assessed cellular responses to identify different functional abilities of red blood cells.
Capillary transit velocity provides a functional measure of red blood cells in sickle cell disease.
Significant differences in transit velocities were observed between healthy and sickle red blood cells.
Microfluidic measurements revealed heterogeneity in responses among sickle cell patients.

Implication

Emerging therapies improve red blood cell function in sickle cell disease, suggesting new evaluation methods.

Abstract

Emerging therapies in sickle cell disease (SCD) aim to restore healthy red blood cell (RBC) function, but they often yield heterogeneous cellular responses. There are no proven techniques to evaluate...

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Cite This Study

Oshabaheebwa et al. (2026) studied this question.

synapsesocial.com/papers/69746090bb9d90c67120a6ae https://doi.org/10.1039/d5lc00769k

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Microfluidic capillary transit velocity as a functional measure for sickle cell disease and in vitro-derived red blood cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Microfluidic capillary transit velocity as a functional measure for sickle cell disease and in vitro-derived red blood cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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