What question did this study set out to answer?

To evaluate how radiation therapy affects systemic immunity in head and neck squamous cell carcinoma (HNSCC).

January 24, 2026Asian Pacific Journal of Cancer Prevention0 citationsOpen Access

From Radiation to Immune Response: A Systematic Review of Systemic Immunomodulation in Squamous Cell Head and Neck Cancer

DFDiogo Valente FerreiraUniversidade do Estado do Rio de Janeiro MSMaria Helena Ornellas de SouzaUniversidade do Estado do Rio de Janeiro DMDaniela MedeirosUniversidade do Estado do Rio de Janeiro

Key Points

To evaluate how radiation therapy affects systemic immunity in head and neck squamous cell carcinoma (HNSCC).
Conducted a systematic review of literature on radiation therapy and immune response in HNSCC.
Analyzed immunophenotyping and peripheral biomarkers related to prognosis.
Identified gaps in existing research calling for standardized longitudinal studies.
Radiation therapy significantly modifies systemic immune responses.
Immunophenotyping and biomarkers show potential for improving treatment personalization.
Need for large-scale studies to validate findings and standardize approaches.

Abstract

RT, either alone or in combined with chemotherapy, significantly alters systemic immunity in HNSCC. Immunophenotyping and peripheral biomarkers show prognostic potential, supporting their integration into personalized treatment strategies. However, standardized, large-scale longitudinal studies are warranted.

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Cite This Study

Ferreira et al. (Thu,) studied this question.

synapsesocial.com/papers/69746090bb9d90c67120a6e1 https://doi.org/https://doi.org/10.31557/apjcp.2026.27.1.19

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