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Systematic review examines systemic immunity changes in head and neck cancer, suggesting personalized treatments may improve outcomes.
RT, either alone or in combined with chemotherapy, significantly alters systemic immunity in HNSCC. Immunophenotyping and peripheral biomarkers show prognostic potential, supporting their integration into personalized treatment strategies. However, standardized, large-scale longitudinal studies are warranted.
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Ferreira et al. (2026) studied this question.
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