Magnetic nanoparticles-catalyzed multi-component green syntheses of tetrazole scaffolds: a review

Tetrazole derivatives serve as fundamental components in the synthesis of biological substances, medicinal agents, and explosive material. Multiple methodologies were utilized to synthesize tetrazole including [3 + 2] cycloaddition, Demko-Sharpless and Ugi-Azide etc. The utilization of catalysts such as magnetic nanoparticles makes the synthesis of tetrazole more efficient, cost-effective and environmentally safe. Magnetic nanoparticles are the green catalyst that are easily separated from the reaction mixture without consuming energy and chemicals. Tetrazole is a core structure of various medicines and other scientific components; therefore, advancement in the synthesis of tetrazole derivatives is always indeed. This study discussed the role of magnetic nanoparticles in the green synthesis of tetrazole and its derivatives. This compilation will surely enhance the development of tetrazole derivatives via green routes for future demand.