Clinical characteristics and whole exome sequencing in JAK2 V617F- and CALR -unmutated essential thrombocythemia

Siraphop Thammayot; Patcharawadee Thongkumkoon; Jeerawan Klangjorhor; Noppamas Panyasit; Piangrawee Niprapan; Nonthakorn Hantrakun; Teerachat Punnachet; Pokpong Piriyakhuntorn; Thanawat Rattanathammethee; Sasinee Hantrakool; Adisak Tantiworawit; Lalita Norasetthada; Chatree Chai‐Adisaksopha; Ekarat Rattarittamrong

doi:10.1080/16078454.2026.2616933

January 21, 2026HematologyOpen Access

Clinical characteristics and whole exome sequencing in JAK2 V617F- and CALR -unmutated essential thrombocythemia

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Key Points

The research aims to explore clinical features and genetic mutations in patients with JAK2 V617F- and CALR-unmutated essential thrombocythemia (ET).
Analyzed clinical data from patients with ET
Utilized whole exome sequencing (WES) for genetic analysis
Compared mutation rates between JAK2 V617F-mutated and unmutated cases
Younger age was noted in JAK2 V617F- and CALR-unmutated ET patients
Lower incidence of thrombosis in these patients compared to JAK2 V617F-mutated cases
WES revealed uncommon and potential driver mutations in the unmutated group

Implication

Clinical characteristics are compared between JAK2 V617F- and CALR-unmutated essential thrombocythemia, suggesting unique mutation profiles.

Abstract

Patients with JAK2V617F- and CALR-unmutated ET tend to present at a younger age and exhibit a lower incidence of thrombosis compared to those with JAK2V617F-mutated ET. The application of WES enabled the detection of uncommon and potential driver mutations in JAK2V617F- and CALR-unmutated ET.

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Cite This Study

Thammayot et al. (2026) studied this question.

synapsesocial.com/papers/697460e9bb9d90c67120aba8 https://doi.org/10.1080/16078454.2026.2616933

View Full Paper

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Clinical characteristics and whole exome sequencing in JAK2 V617F- and CALR -unmutated essential thrombocythemia

Key Points

Implication

Abstract

Discussion

Cite This Study

Clinical characteristics and whole exome sequencing in JAK2 V617F- and CALR -unmutated essential thrombocythemia

Key Points

Implication

Abstract

Discussion

Cite This Study

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