Key result
This review discusses the structure, function, and potential diagnostic and prognostic roles of CALR and JAK2V617F mutations in patients with essential thrombocythemia.
Why the study?
What is the diagnostic and prognostic role of CALR and JAK2V617F mutations in essential thrombocythemia?
What is the diagnostic and prognostic role of CALR and JAK2V617F mutations in essential thrombocythemia?
CALR and JAK2V617F mutations serve as important diagnostic and prognostic markers in essential thrombocythemia.
May aid ET diagnosis and prognosis now; leaves open prospective validation before routine use.
Mutation in calreticulin (CALR) has been recently detected in essential thrombocythemia (ET) patients lacking JAK2V617F mutation. The absence of JAK2V617F mutation in 50% of patients with ET has indicated the importance of new markers for disease diagnosis, including CALR. Considering the detection of CALR in these patients, in this paper we study the structure and function of CALR protein and JAK2V617F as well as their diagnostic and prognostic role in ET patients.
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Najmaldin Saki (2015) conducted a review in Essential thrombocythemia. CALR and JAK2V617F mutations was evaluated. This review discusses the structure, function, and potential diagnostic and prognostic roles of CALR and JAK2V617F mutations in patients with essential thrombocythemia.
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