Comparative Evaluation of the Anti-Plaque and Anti-Gingivitis Efficacy of Two Fluoridated Toothpastes in Children: A Multicentric Randomized Controlled Trial

Introduction: Dental plaque and gingivitis are prevalent concerns in pediatric populations. This multicentric randomized controlled trial aimed to compare the anti-plaque and anti-gingivitis efficacy of two fluoridated toothpastes, one experimental (Dentoshine) and one commercially available tooth paste among children aged 6–12 years. Materials and Methods: A total of 300 participants were randomly assigned in a 1:1 ratio to either the experimental or control group. Clinical parameters, including plaque index (PI) and gingival index (GI), were recorded at baseline, first follow-up, second follow-up, and third follow-up. Data were analyzed using independent t -tests, repeated measures analysis of variance (ANOVA), and Bonferroni post hoc tests. Results: Participant distribution was comparable across genders and age groups. Both toothpaste formulations showed significant reductions in plaque and gingival scores over time. In the experimental group, repeated measures ANOVA showed a significant decrease in PI scores ( F = 53.695, P = 0.001), with the most substantial reduction between baseline and the third follow-up (mean difference = 0.874, P < 0.001). Similarly, the control group showed significant plaque reduction ( F = 55.82, P = 0.000). GI scores also improved significantly in both groups, with the Dentoshine toothpaste showing a greater decline ( F = 81.431, P < 0.001). Post hoc analysis confirmed that improvements were statistically significant from the second follow-up onward. Conclusion: Both fluoridated toothpaste formulations were effective in reducing plaque and gingivitis with regular use. However, the Dentoshine toothpaste demonstrated slightly superior performance in long-term plaque and gingival health outcomes among children.