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January 24, 2026Open Access

Wolfram Syndrome: A Series of 4 Cases

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Authors

KGK. GorgiMCM. ChaoucheKRKaoutar Rifai

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Overview

Case series reveals poor prognosis and treatment strategies in Wolfram Syndrome, suggesting need for early intervention.

Key Points

  • This research aims to detail clinical presentations and outcomes of Wolfram Syndrome cases.
  • Documented clinical features of four patients diagnosed with Wolfram Syndrome
  • Conducted genetic testing for WFS1 gene mutations
  • Evaluated treatment responses including insulin therapy and incretin analogs
  • All cases exhibited typical symptoms of Wolfram Syndrome
  • Patients had a mean life expectancy of 39 years
  • Treatment with insulin was standard, but early use of incretin analogs showed potential benefit

Cite This Study

Gorgi et al. (2025) studied this question.

synapsesocial.com/papers/6974610cbb9d90c67120adf5https://doi.org/10.5281/zenodo.18302898
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 141 A case of wolfram syndrome: understanding a rare genetic disorder2024 · 1 citations
  2. 260 Wolfram syndrome with variable presentation: case series2024 · 1 citations
  3. 3Revision of diagnosis in a child with type 1 diabetes mellitus due to appropriate genetic testing – Wolfram Syndrome2026
  4. 4A Case Study on Wolfram Syndrome: Medical and Nursing Management2025
  5. 5Beyond Vision and Hearing: A Case Report of Wolfram Syndrome2024