Experimental analysis finds that Brij-rich micelles improve drug solubilization in hydrophobic drugs, indicating design considerations for micellar carriers.
Micellar stability and solubilization efficiency are not always correlated. Brij-rich micelles showed superior ketoprofen solubilization, whereas overly stabilized ternary systems limited drug loading. These findings highlight the need to balance stability and flexibility when designing micellar carriers for hydrophobic BCS class II drugs.
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Agatić et al. (2026) studied this question.
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