Drug-Dependent Modulation of Micelle Morphology and Encapsulation in Triton X-100 Systems

Melissa J Mitchell; Hrachya Ishkhanyan; Martin Ulmschneider; Christian D. Lorenz

doi:10.1039/d5cp04113a

January 1, 2026Physical Chemistry Chemical PhysicsOpen Access

Drug-Dependent Modulation of Micelle Morphology and Encapsulation in Triton X-100 Systems

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Key Points

This study aims to examine how drugs influence the shape and drug-carrying ability of micelles.
Performed all-atom molecular dynamics simulations
Analyzed micelle structures and drug interactions
Investigated the solubility effects of drugs on micelle systems
Changes in micelle morphology were observed with different drugs
Enhanced encapsulation efficiency of poorly water-soluble drugs was achieved
Quantitative improvements in solubility were noted for specific drug-micelle combinations

Implication

Investigates drug delivery efficiency in micelle systems, suggesting improvements for poorly soluble drugs.

Abstract

Micelle-based drug delivery systems offer promising strategies for enhancing the solubility and bioavailability of poorly water-soluble drugs. In this study, we employed all-atom molecular dynamics simulations to investigate the structural...

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Cite This Study

Mitchell et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf701faef96ed7f05894c https://doi.org/10.1039/d5cp04113a

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Drug-Dependent Modulation of Micelle Morphology and Encapsulation in Triton X-100 Systems

Key Points

Implication

Abstract

Discussion

Cite This Study

Drug-Dependent Modulation of Micelle Morphology and Encapsulation in Triton X-100 Systems

Key Points

Implication

Abstract

Discussion

Cite This Study

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