Glutathione-Responsive Degradable Amphiphilic Polyester-Based Nanocarrier for Targeted Drug Delivery

Key Points

• The aim is to develop a nanocarrier that breaks down in the presence of glutathione to target cancer cells more effectively.
• Synthesis of an amphiphilic polyester-based nanocarrier
• Characterization of disulfide bond responsiveness to glutathione
• In vitro tests to evaluate drug delivery capabilities in cancerous cells
• The nanocarrier demonstrated enhanced drug release in the presence of glutathione
• Targeted drug delivery was confirmed to be more effective in cancer cells compared to non-cancerous cells
• Improved treatment outcomes were suggested based on preliminary observations of efficacy