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January 22, 2026Endocrinology and MetabolismOpen Access

Associations between Metabolic Syndrome Indicators and Colon Polyps: A Mendelian Randomization Study

Dongya Chen Hong Xu Zhaolin Zhang Fang Chen Qingqing Lu Feng Pan

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Key Points

This research aims to explore how indicators of metabolic syndrome are linked to the risk of developing colon polyps.
Utilized Mendelian randomization to investigate genetic variants related to metabolic traits
Analyzed associations between obesity-related traits, cholesterol, and triglycerides with colon polyp risk
Obesity-related traits, total cholesterol (TC), and triglycerides (TG) are associated with an increased risk of colon polyps
High-density lipoprotein cholesterol (HDL-C) appears to have a protective effect against colon polyps

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Implication

Mendelian randomization examines how metabolic syndrome indicators affect colon polyps, suggesting potential risk factors.

Abstract

Obesity-related traits, TC, and TG may increase the risk of colon polyps, while HDL-C may have a protective effect.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/697461a8bb9d90c67120b857 https://doi.org/10.3803/enm.2025.2379

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