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June 10, 2025Discover OncologyOpen Access

Assessing the influence of metabolic syndrome on thyroid cancer: insights from a Mendelian randomization approach

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Authors

XRXiaosong RuZSZiying SuYGYong Guo

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Overview

Mendelian randomization study reveals an increased risk of thyroid cancer with metabolic syndrome in European populations, suggesting a protective effect of high-density lipoprotein cholesterol.

Key Points

  • To evaluate the potential causal link and genetic correlation between metabolic syndrome, its individual components, and thyroid cancer risk.
  • Extracted instrumental variables for metabolic syndrome and its lipid components from publicly accessible genome-wide association study (GWAS) databases.
  • Conducted two-sample Mendelian randomization using inverse variance weighted (IVW) analysis and sensitivity tests on thyroid cancer data from a Finnish cohort.
  • Assessed genetic correlation between metabolic syndrome traits and thyroid cancer using linkage disequilibrium score regression (LDSC).
  • Metabolic syndrome displayed a significant positive causal relationship with thyroid cancer risk (OR = 1.7003, 95% CI = 1.2631–2.2888, P = 0.0005).
  • High-density lipoprotein cholesterol demonstrated a protective causal association against thyroid cancer (OR = 0.7868, 95% CI = 0.6822–0.9076, P = 0.0010).
  • Linkage disequilibrium score regression showed no statistically significant genome-wide genetic correlation between metabolic syndrome components and thyroid cancer.

Cite This Study

Ru et al. (2025) studied this question.

synapsesocial.com/papers/6a993f2af3ae593e01363adahttps://doi.org/10.1007/s12672-025-02760-4
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Also Consider

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  1. 1Metabolic syndrome and cancer risk: A two-sample Mendelian randomization study of European ancestry2024 · 12 citations
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  4. 4Thyroid Cancer in Patients with Metabolic Syndrome or Its Components: A Nationwide Population-Based Cohort Study2022 · 22 citations
  5. 5Mendelian Randomization as an Approach to Assess Causality Using Observational Data2016 · 2,506 citations