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January 24, 2026DiabetologiaOpen Access

Blood DNA methylation markers are associated with diabetic kidney disease progression in type 1 diabetes

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Authors

ASAnna SyreeniEDEmma DahlströmLSLaura J. Smyth

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Overview

Epigenome-wide association studies reveal DNA methylation biomarkers for DKD progression in type 1 diabetes, suggesting new diagnostic pathways.

Key Points

  • The study aims to investigate the relationship between DNA methylation markers and the progression of diabetic kidney disease in type 1 diabetes.
  • Conducted epigenome-wide association studies (EWASs) using DNA methylation data from blood samples.
  • Included 403 participants with normal albumin excretion rate (AER) and 372 with severe albuminuria.
  • Followed DKD progression based on a decrease in estimated glomerular filtration rate (eGFR) and end-stage kidney disease (ESKD).
  • Performed replication in additional cohorts and integrated findings with genetic and proteomic data.
  • Identified 11 methylation sites associated with DKD progression (p < 9.4 × 10−8).
  • Found that methylation at cg01730944 near the CDKN1C gene was linked to early-stage DKD progression independently of baseline eGFR.
  • Identified cg17944885 as a significant ESKD risk locus (p = 2.6 × 10−17).
  • Supported associations between certain proteins and severe kidney endpoints derived from the UK Biobank.

Cite This Study

Syreeni et al. (2026) studied this question.

synapsesocial.com/papers/697461a8bb9d90c67120b928https://doi.org/10.1007/s00125-025-06661-7
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