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July 22, 2025

Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end stage renal disease

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Authors

JLJianjun LiuXZXiaohong ZhouDSDianchun Shi

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Overview

Epigenome-wide association study reveals 52 methylation loci in ESRD cases, suggesting inflammation's role in kidney decline.

Key Points

  • Identified 52 ESRD-associated differentially methylated CpG loci linked to multiple kidney diseases.
  • The study analyzed data from 704 controls and 1031 ESRD cases in two independent cohorts.
  • Factors like inflammation and renal fibrosis play crucial roles in the progression of end-stage renal disease.
  • Findings suggest potential prognostic biomarkers for ESRD risk and related complications, aiding in management.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd63ahttps://doi.org/10.21203/rs.3.rs-7071877/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end stage renal disease2025
  2. 2Blood DNA methylation markers are associated with diabetic kidney disease progression in type 1 diabetes2026 · 4 citations
  3. 3LONGITUDINAL EPIGENOME-WIDE DNA METHYLATION AND GENE EXPRESSION SIGNATURES ASSOCIATED WITH INCIDENT CHRONIC KIDNEY DISEASE IN AN AFRICAN POPULATION2026
  4. 4Novel approaches and applications in identifying DNA methylation markers of cardio-kidney-metabolic disease.2025
  5. 5Immune Microenvironment and Genetic Signatures of End-Stage Renal Disease and Their Association with Sepsis: Insights from Public Transcriptomic Data and a Multicenter Clinical Cohort2026