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April 15, 2026BiomedicinesOpen Access

Immune Microenvironment and Genetic Signatures of End-Stage Renal Disease and Their Association with Sepsis: Insights from Public Transcriptomic Data and a Multicenter Clinical Cohort

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Authors

SWSheng-Huei WangKYK. M. YangCSCHAU-CHYUN SHEU

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Overview

Explores the relationship between end-stage renal disease and sepsis, indicating a shared immune vulnerability.

Key Points

  • The research aims to investigate the connection between end-stage renal disease (ESRD) and sepsis through transcriptomic analysis and clinical evaluation.
  • Retrieved transcriptomic data from Gene Expression Omnibus.
  • Used Gene Set Enrichment Analysis and XGBoost for bioinformatics.
  • Conducted a multicenter cohort study on patients with sepsis from CRAB pneumonia.
  • Compared clinical outcomes between ESRD and non-ESRD patients.
  • Identified extensive gene expression changes in ESRD patients.
  • Found disruptions in immune signaling and vesicular transport pathways.
  • Reported higher SOFA scores and increased mortality rates in ESRD patients compared to those with normal renal function.
  • Confirmed similar immune characteristics between ESRD and sepsis.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69df2b04e4eeef8a2a6aff0chttps://doi.org/10.3390/biomedicines14040885
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