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October 3, 2025Frontiers in ImmunologyOpen Access

Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury

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Authors

TCTianle ChengYXYong XuZLZiwei Liu

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Overview

This analysis identifies neutrophil subtypes and molecular drivers in acute kidney injury, suggesting potential biomarkers for sepsis.

Key Points

  • Neutrophil heterogeneity reveals four subtypes linked to sepsis-associated acute kidney injury.
  • Significant increases in pro-inflammatory neutrophils (40.53%) noted in sepsis compared to controls (4.19%).
  • Multi-omics approach utilized single-cell and bulk RNA sequencing alongside animal and human validation.
  • Findings highlight molecular drivers like peptidyl arginine deiminase 4, suggesting novel therapeutic targets.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/68e034f7f0e39f13e7fa330dhttps://doi.org/10.3389/fimmu.2025.1637692
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  4. 4Uncovering molecular markers of the microvascular endothelial response in sepsis-associated acute kidney injury: a translational study in mice and humans2025
  5. 5Risk model based on neutrophil-related genes constructs to assess prognosis and immune landscape in sepsis2025