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January 24, 2026Open Access

The differential effects of lutein and zeaxanthin supplementation on myopia prevention in adolescents: a systematic review and Meta-analysis

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Authors

PLPei LiChengdu University of Traditional Chinese MedicineYMYa MoChengdu University of Traditional Chinese MedicineJDJun-Guo Duan

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Implication

Systematic review reveals lutein and zeaxanthin supplementation significantly reduces myopia in adolescents, suggesting a viable prevention strategy.

Key Points

  • This review aims to evaluate the effects of lutein and zeaxanthin on myopia prevention specifically in adolescents.
  • Systematic search of randomized controlled trials from 2014 to 2023
  • Quality assessment using the Cochrane risk of bias method
  • Meta-analysis with standardized mean differences calculated using Stata
  • Subgroup analyses based on dosage, intervention duration, and geographic variation
  • Assessment of publication bias using Egger's test.
  • Lutein and zeaxanthin supplementation significantly reduced axial length elongation (SMD=-0.40, P=0.001)
  • Increased macular pigment optical density (SMD=0.50, P=0.010)
  • Enhanced visual sensitivity (SMD=0.53, P=0.008)
  • High doses and longer interventions yielded greater benefits compared to lower doses and shorter durations

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/697461a8bb9d90c67120b938https://doi.org/10.18240/ijo.2026.02.21
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1LUTEIN AND ZEAXANTHIN IN THE PREVENTION AND TREATMENT OF AGE-RELATED EYE DISEASES: A REVIEW OF EFFICACY AND BIOAVAILABILITY STUDIES WITH A FOCUS ON OCULAR AND COGNITIVE HEALTH2026
  2. 2From Supplements to Sight: Quantifying the Impact of Lutein and Carotenoid on Age‐Related Macular Degeneration—A Systematic Review and Meta‐Analysis of Randomized Controlled Trials2026
  3. 3The Effects of Lutein/ Zeaxanthin (Lute-Gen®) on Eye Health, Eye Strain, Sleep Quality, and Attention in High Electronic Screen Users: A Randomized, Double-Blind, Placebo-Controlled Study2024
  4. 4Lutein and Zeaxanthin Supplementation Improves Dynamic Visual and Cognitive Performance in Children: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study2024 · 35 citations
  5. 5The effects of lutein, zeaxanthin and anthocyanins supplementation on visual function and vision protection in healthy school-aged children: a single-center prospective randomized controlled study2026