Enantioselective Michael additions promoted by a bifunctional charge-activated thiourea catalyst

Josiah Nisly; Steven R. Kass

doi:10.1039/d5ob01845e

January 1, 2025Organic & Biomolecular Chemistry

Enantioselective Michael additions promoted by a bifunctional charge-activated thiourea catalyst

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Key Points

The aim is to synthesize a new bifunctional thiourea catalyst and evaluate its enantioselective activity.
Development of a new bifunctional thiourea catalyst with a methylated pyridinium ion and chiral amine.
Comparison of catalytic activity against Takemoto's catalyst in Michael addition reactions.
The new organocatalyst shows increased activity compared to analogous thiourea catalysts.
Significant improvement in enantioselectivity observed during Michael addition reactions.

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Implication

Bifunctional thiourea catalyzes enantioselective Michael additions, indicating enhanced reactivity in various reactions.

Abstract

A new bifunctional thiourea featuring a methylated pyridinium ion and a chiral amine is reported. This readily prepared organocatalyst is more active than its analogous 3,5bis(trifluoromethyl)phenyl substituted thiourea ("Takemoto's catalyst"),...

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Nisly et al. (2025) studied this question.

synapsesocial.com/papers/6975b1a9feba4585c2d6d1e5 https://doi.org/10.1039/d5ob01845e

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Enantioselective Michael additions promoted by a bifunctional charge-activated thiourea catalyst

Key Points

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Abstract

Discussion

Cite This Study

Enantioselective Michael additions promoted by a bifunctional charge-activated thiourea catalyst

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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