Abstract Background: Dentinal hypersensitivity (DH) is a frequent condition producing sharp, transient pain in response to external stimuli. Conventional desensitizing agents often provide only partial or short-term relief. This study evaluated the effectiveness of combining ozone therapy with desensitizing toothpaste compared with toothpaste alone in DH management. Methods: A randomized controlled trial was conducted on 80 patients aged 18–65 years with moderate-to-severe DH at the Department of Oral Medicine and Radiology, Kalinga Institute of Dental Sciences, Bhubaneswar. Patients were allocated into two groups: the test group ( n = 40) received ozone therapy (ozonated olive oil and ozone gas) plus desensitizing toothpaste, and the control group ( n = 40) received 5% potassium nitrate toothpaste. Sensitivity was assessed at baseline and follow-up intervals (1 week, 2 weeks, 1 month, 3 months, and 6 months) using the Visual Analog Scale (VAS), Air Blast Sensitivity Test, and Sensitivity Clinical Assessment Scale (SCASS). Scanning electron microscopy was performed to assess dentinal tubule occlusion. Results: Both the groups showed significant sensitivity reduction. The test group achieved greater mean decreases in VAS (5.05 ± 1.11) and SCASS (5.23 ± 1.10) compared with the control group (VAS: 2.35 ± 1.03 and SCASS: 2.28 ± 0.88). Improvements in the test group were sustained for 6 months, whereas control results plateaued. No adverse effects were reported. Conclusion: Ozone therapy with desensitizing toothpaste offers enhanced, long-lasting relief of dentinal hypersensitivity. Its antimicrobial, anti-inflammatory, and remineralizing actions support dentinal repair and patient comfort, representing a safe and effective adjunct to standard care.
Sangamesh et al. (Thu,) studied this question.
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