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Research Paper | Synapse

January 25, 20260 citations

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In vitro activity of gepotidacin against a challenging panel of multidrug-resistant Neisseria gonorrhoeae isolates.

MCMichelle ColeNational Security Agency MDMichel DoumithKing Saud bin Abdulaziz University for Health Sciences AVAnna VickersPublic Health Agency

Key Points

This research aims to evaluate the in vitro effectiveness of gepotidacin against multidrug-resistant Neisseria gonorrhoeae isolates.
Evaluated gepotidacin activity against a panel of ceftriaxone-resistant gonococcal clinical isolates.
Conducted structural analysis of strains for alterations affecting drug binding.
Gepotidacin demonstrated activity against ceftriaxone-resistant Neisseria gonorrhoeae isolates.
The GyrA A92P alteration did not affect the binding of gepotidacin.

Abstract

Overall, gepotidacin was active in vitro against this challenging panel of ceftriaxone-resistant gonococcal clinical isolates. Gepotidacin activity does not seem to be affected in this ceftriaxone-resistant set of strains. A structural analysis suggests that the rare GyrA A92P alteration identified in this study does not affect gepotidacin binding.

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Cite This Study

Cole et al. (Mon,) studied this question.

synapsesocial.com/papers/6975b1cefeba4585c2d6d450 https://doi.org/https://doi.org/10.1093/jac/dkag001