Background: Metabolic syndrome has been recognized as a significant public health issue closely related to dysbiosis and systemic inflammation, which are influenced by gut microbiota and its metabolites. Objective: This review focuses on the Short-Chain Fatty Acids (SCFAs) from buckwheat in modifying gut microbiota and immune response to combat metabolic syndrome. We provide an overview of studies on the substantial function of buckwheat-derived SCFAs in the interaction between gut microbiota and the immune system, particularly in metabolic syndrome. Methods: A detailed literature review was performed from 2015 to 2025, utilizing PubMed, ScienceDirect, SpringerLink, and Google Scholar databases. The data was analyzed descriptively and systematically. Results and Discussion: Buckwheat's resistant starch, polyphenols, and bioactive peptides promote SCFA production, reduce chronic inflammation, and lower the risk of metabolic syndromes. However, the heterogeneity in gut microbiota response among subjects underlines the relevance of individualized nutrition. Future research should prioritize large-scale trials to validate these findings and examine long-term impacts. Conclusion: The function of SCFAs produced by buckwheat as an alternative functional food to mitigate metabolic syndrome was explored in this review.
Desfita et al. (Fri,) studied this question.