Multi-responsive upconversion/organic porous silicon nanocomposite for controlled drug release via NIR irradiation and tumor microenvironment stimuli

Key Points

• The study aims to create a nanocomposite that can release drugs in response to specific stimuli for targeted cancer therapy.
• Developed UCNP@organosilica nanocapsules
• Utilized GSH-triggered degradation for drug release
• Employed NIR/pH/GSH stimuli for controlled release
• Achieved targeted drug release in tumor environments
• Enabled low-toxicity chemotherapy
• Demonstrated tumor cell ablation capability