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January 25, 2026International Journal of Molecular SciencesOpen Access

Emerging Role of the NLRP3 Inflammasome in the Onset of Oral Diseases and Its Potential as a Therapeutic Target

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Authors

MAMohammad Ibtehaz AlamUniversity of DhakaFFFatima FarhanaESEiko SakaiNagasaki University

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Implication

This review discusses NLRP3 inflammasome's involvement in oral diseases, suggesting therapeutic strategies for improved outcomes.

Key Points

  • The aim is to explore the role of the NLRP3 inflammasome in oral diseases and its therapeutic implications.
  • Review of current and past literature on NLRP3 and oral diseases
  • Analysis of pathogenic mechanisms involving NLRP3
  • Evaluation of emerging pharmacological strategies targeting NLRP3
  • Discussion on preclinical findings and clinical translation challenges
  • NLRP3 activation contributes to inflammation, tissue degradation, and bone resorption in oral diseases.
  • Inflammasome inhibitors and natural compounds can reduce tissue damage in preclinical studies.
  • Current clinical applications of inflammasome-targeted therapies remain limited.

Cite This Study

Alam et al. (2026) studied this question.

synapsesocial.com/papers/6975b20efeba4585c2d6d7dchttps://doi.org/10.3390/ijms27021098
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