What question did this study set out to answer?

To examine the characteristics and advantages of glutathione-responsive cyclodextrin nanosponges in drug delivery.

January 25, 2026Expert Opinion on Drug Delivery0 citations

Redox responsive cyclodextrin-based drug delivery systems: a special insight to glutathione responsive CD-nanosponges

SMSanaz MohammadvalipourTabriz University of Medical Sciences ZIZiba IslambulchilarTabriz University of Medical Sciences HVH ValizadehTabriz University of Medical Sciences

Key Points

To examine the characteristics and advantages of glutathione-responsive cyclodextrin nanosponges in drug delivery.
Reviewed existing literature on cyclodextrin nanosponges
Discussed structural properties and responsiveness
Analyzed cross-linking density effects on drug delivery
Identified key relationships between structure and drug release effectiveness
Showed that cross-linking density influences responsiveness to glutathione
Highlighted advantages of using nanosponges in targeted drug delivery

Abstract

This review highlights glutathione-responsive cyclodextrin nanosponges as an advanced evolution of CD-based carriers, emphasizing emerging structure - property - responsiveness relationships rather than exhaustive coverage. By discussing nanosponge architecture and cross-linking density.

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