Photocatalysis enables efficient decarboxylative coupling of carboxylic acids, aldehydes, and amines, suggesting a new synthetic route.
Photocatalysis has emerged as a promising strategy for unlocking novel reactivity from commercially accessible feedstocks. This work reports a three-component reaction of aldehydes, aliphatic secondary amines, and aliphatic carboxylic acids, enabled by a synergistic dual catalytic system merging photoredox and Lewis acid catalysis. This approach provides a modular route to access synthetically valuable α-branched tertiary amines in good yields.
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Zhu et al. (2026) studied this question.
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