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Systematic review reveals uncertain effects of hyperoxemia on mortality and outcomes in traumatic brain injury, suggesting further research is needed.
This systematic review and meta-analysis do not provide sufficient evidence to discourage the use of moderate hyperoxemia in TBI patients. Exploratory analyses suggesting potential benefits from early moderate hyperoxemia require further validation in selected patients. High-quality prospective studies are urgently needed to determine the optimal use of oxygen therapy in TBI.
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Fornaciari et al. (2026) studied this question.
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