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January 25, 2026Chemistry & Biodiversity

Comprehensive In Vitro and In Silico Evaluation of Foeniculum vulgare Seeds: Phytochemicals, Antioxidant Power, Antimicrobial Action, and Anticoagulant Activity

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Authors

ADAziz DrioicheInstituts Supérieurs des Professions Infirmières et Techniques de SantéOKOmkulthom Al kamalyPrincess Nourah bint Abdulrahman UniversityMOMohamed El OuardiUniversité Moulay Ismail de Meknes

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Implication

In vitro and in silico assessment of Foeniculum vulgare reveals significant bioactive properties, suggesting therapeutic potential.

Key Points

  • This research aims to evaluate the phytochemical profiles and bioactivities of Foeniculum vulgare seeds and their extracts.
  • Conducted comparative analysis of aqueous extracts and essential oil
  • Assessed antioxidant capacity using DPPH, FRAP, and TAC methods
  • Tested antimicrobial activities against various bacteria and fungi
  • Evaluated anticoagulant effects via prothrombin time and activated partial thromboplastin time assessments
  • Performed molecular docking studies targeting β-lactamases and thrombin.
  • Decoction showed highest phenolic (56.8 mg GAE/g) and flavonoid (22.8 mg QE/g) content
  • DPPH radical-scavenging activity measured at IC 50 = 228.8 µg/mL
  • Aqueous extract inhibited Acinetobacter baumannii growth (MIC = 600 µg/mL)
  • Essential oil inhibited Candida parapsilosis (MIC = 1200 µg/mL)
  • Aqueous extract extended aPTT significantly, indicating anticoagulant activity.

Cite This Study

Drioiche et al. (2026) studied this question.

synapsesocial.com/papers/6975b28afeba4585c2d6dff0https://doi.org/10.1002/cbdv.202502590
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