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January 25, 2026Renal Replacement TherapyOpen Access

Effectiveness of comprehensive medical care support by healthcare professionals, including nurses, in patients with chronic kidney disease: a systematic review and meta-analysis

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Key result

Comprehensive medical care support improves physical function, quality of life, and self-management in CKD patients.

Why the study?

The study aimed to evaluate the effectiveness of comprehensive medical care support by healthcare professionals, including nurses, for patients with chronic kidney disease in the preservation phase.

Does multidisciplinary comprehensive medical care support, including nurses, improve renal function, blood pressure, physical function, and quality of life in patients with dialysis-independent chronic kidney disease?

Population

Patients aged ≥ 18 years with dialysis-independent CKD across 20 randomized controlled trials

Design

Systematic review and meta-analysis of randomized controlled trials

Authors

KHKotaro HitoshiNINaotaka IkedaTKToshiki Kutsuna

Discussion

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Overview

Supports multidisciplinary CKD care including nurses; reinforces consensus on chronic disease management benefits.

Key Points

  • The research evaluates the benefits of comprehensive medical care support provided by healthcare professionals, including nurses, for patients with chronic kidney disease.
  • Literature searches conducted in PubMed and Ichushi-Web to identify relevant studies.
  • Inclusion of randomized controlled trials with patients aged ≥ 18 years and dialysis-independent chronic kidney disease.
  • Studies must involve nurses in the intervention and demonstrate comprehensive support by multiple healthcare professionals.
  • 20 studies included in the review, with 14 eligible for meta-analysis.
  • Significant positive effects of comprehensive medical care support observed in physical function, quality of life, and self-management ability.
  • No significant changes noted in renal function and blood pressure between intervention and control groups.

Structured PICO

Does multidisciplinary comprehensive medical care support, including nurses, improve renal function, blood pressure, physical function, and quality of life in patients with dialysis-independent chronic kidney disease?

P
Population
Adults aged ≥ 18 years with dialysis-independent chronic kidney disease (CKD) in the preservation phase (20 RCTs included in systematic review, 14 eligible for meta-analysis).
I
Intervention
Comprehensive medical care support (CMCS) provided by a multidisciplinary team of two or more healthcare professionals, including nurses.
C
Comparator
Usual care or standard care.
O
Outcome
Renal function (including the number of patients whose condition progressed to end-stage renal disease) and blood pressure.surrogate

Multidisciplinary team-based comprehensive medical care support, including nursing involvement, improves physical function, quality of life, and self-management in patients with CKD, though it does not significantly impact renal function or blood pressure.

Limitations

  • Substantial heterogeneity across studies

Cite This Study

Hitoshi et al. (2026) studied this question. Comprehensive medical care support by healthcare professionals improved physical function, quality of life, and self-management in patients with chronic kidney disease.

synapsesocial.com/papers/6975b28afeba4585c2d6e050https://doi.org/10.1186/s41100-026-00704-4
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