⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

January 23, 2026

Multi-Site Validation of a Newly FDA-Cleared Automated Methotrexate Immunoassay for Therapeutic Drug Monitoring.

Shaimaa Maher Vincent Buggs Patrick Ravelo Lu Song Imir G. Metushi

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to validate the effectiveness of the Roche ONLINE TDM MTX assay for therapeutic drug monitoring.
Multi-site validation approach.
Automated immunoassay technique.
Measurement of methotrexate levels.
The assay demonstrated robust quantification of methotrexate.
Clinically adequate performance was established for therapeutic monitoring.

Implication

Multi-site validation shows robust methotrexate quantification in drug monitoring, indicating clinical adequacy.

Abstract

The Roche ONLINE TDM MTX assay is a robust and clinically adequate method for methotrexate quantification and therapeutic drug monitoring.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Maher et al. (2026) studied this question.

synapsesocial.com/papers/6975b28afeba4585c2d6e11f https://doi.org/10.1093/jalm/jfaf189

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Analytical Validation of a Second-Generation Methotrexate ImmunoassayOriginal Research · 2025
2Novel LC-MS/MS Method for Measuring Methotrexate in High-Dose Therapy: A Comparative Study with Commercial EMIT and EIA Immunoassays2025
3Novel LC-MS/MS method for measuring methotrexate in high-dose therapy: a comparative study with commercial EMIT and EIA immunoassays2025
4Clinical feasibility of a label-free SERS assay for therapeutic drug monitoring of methotrexate2024 · 8 citations
5Verification of methotrexate dosage method on Alinity c Abbott automated system in the biochemistry laboratory of CHU Mohammed VI d'Oujda2024