What question did this study set out to answer?

This research aims to investigate the biological effects of polynucleotides from Paeonia lactiflora on collagen accumulation in skin cells.

Paeonia lactiflora Callus-Derived Polynucleotides Enhance Collagen Accumulation in Human Dermal Fibroblasts

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Plant-derived polynucleotides enhance collagen accumulation in human dermal fibroblasts, suggesting a new option for skin regeneration.

This research aims to investigate the biological effects of polynucleotides from Paeonia lactiflora on collagen accumulation in skin cells.
Extracted polynucleotides from Paeonia lactiflora callus.
Evaluated effects on human dermal fibroblasts through treatments and assays.
Analyzed receptor expression, signaling pathways, and collagen production.
PL-PN treatment led to increased cell viability and pro-collagen I α1 secretion.
Activation of cAMP/PKA/CREB pathway was observed along with G1/S transition enhancement.
Significant reduction in NF-κB localization and downregulation of MMPs indicating reduced inflammation.
Enhanced collagen and elastin deposition through increased TGF-β maturation and related signaling.

Hwang et al. (2026) studied this question.

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