Network meta-analysis demonstrates superior efficacy and safety of targeted biologics in chronic rhinosinusitis with nasal polyps, suggesting viable long-term management options.
All evaluated biological agents demonstrated efficacy superior to placebo, with IL-4 receptor alpha inhibitors showing the largest and most consistent benefits. All treatments exhibited favorable safety profiles, supporting their use for long-term management of CRSwNP.
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Wang et al. (2026) studied this question.
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