Post-hoc analysis demonstrates ALP's association with pruritus in cholestatic symptoms, indicating its potential as a surrogate endpoint.
This study shows a significant association between ALP and pruritus, the most prominent cholestatic symptom. Our results corroborate the hypothesis that ALP has construct validity as cholestatic marker, thereby supporting its role as potential surrogate endpoint for clinical trials.
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Middelburg et al. (2026) studied this question.
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