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February 13, 2026Open Access

Pruritus is common in primary sclerosing cholangitis, persists over time, and its intensity is associated with disease severity: a multicentre, prospective observational study

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Authors

NHNasir HussainUniversity of the PunjabRMRodrigo Vieira MottaUGUsha GungabissoonCentre for Innovation in Regulatory Science

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Overview

Prospective observational study identifies pruritus intensity in primary sclerosing cholangitis, suggesting links to disease progression.

Key Points

  • This research aims to evaluate the prevalence and intensity of pruritus in primary sclerosing cholangitis and its association with disease severity.
  • Conducted a multicenter, prospective observational study with 220 PSC patients.
  • Participants assessed symptoms using itch numerical rating scale (NRS) and 5D-itch tool.
  • Tracked clinical, radiological, and biochemical factors over 48 weeks to evaluate pruritus severity.
  • 116 out of 220 patients reported pruritus, with 56 scoring NRS ≥4 for severe itch.
  • Median 5D-itch scores were higher in patients with cirrhosis (11.0) compared to those without (8.0).
  • 61.5% of patients with severe pruritus experienced persistent intensity over 48 weeks.

Cite This Study

Hussain et al. (2025) studied this question.

synapsesocial.com/papers/698ebf5085a1ff6a930169dfhttps://doi.org/10.5167/uzh-291352
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pruritus is common in primary sclerosing cholangitis, persists over time, and its intensity is associated with disease severity2025 · 7 citations
  2. 2Pruritus Is Frequent and Persistent and Impacts Quality of Life Among Patients With Primary Sclerosing Cholangitis2026
  3. 3A multinational survey assessing the impact and burden of pruritus on patients with primary sclerosing cholangitis2026 · 1 citations
  4. 4Pruritus and health-related quality of life in chronic liver disease: a longitudinal, survey-based cohort study2025 · 3 citations
  5. 5Pervasive role of pruritus in impaired quality of life in patients with primary biliary cholangitis: Data from the GLIMMER study2025