Research reveals how acetyl-CoA influences mitophagy, impacting mitochondrial quality control and KRAS inhibitor resistance.
A recent study published in Nature by Zhang et al. reported that cytosolic acetyl-CoA functions as a signaling metabolite that regulates NLRX1-dependent mitophagy during nutrient stress. This discovery reveals a metabolic checkpoint for mitochondrial quality control and provides new insights into KRAS inhibitor resistance.
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Chen et al. (2026) studied this question.
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