What question did this study set out to answer?

January 25, 20260 citations

Single-cell transcriptomics uncovers malignant potential of gallbladder adenomyomatosis and identifies PRDX1+ immunosuppressive macrophages in gallbladder carcinoma.

YXYan XiaTongren Hospital XZXiaoqing ZhangInternational Peace Maternity & Child Health Hospital YLYi LiuNingbo University

Key Points

This research aims to explore the malignant potential of gallbladder adenomyomatosis and identify markers in gallbladder carcinoma.
Utilized single-cell transcriptomics to analyze gallbladder adenomyomatosis (GBA) and gallbladder carcinoma (GBC).
Assessed expression levels of CCL20, CCL5, and PRDX1 as potential markers.
Investigated the immune microenvironment in relation to malignant growth.
GBA was found to possess malignant potential at epithelial and immune levels.
PRDX1+ macrophages identified as immunosuppressive components in GBC.
CCL20 and CCL5 expressions linked to identifying high-risk GBA cases.

Abstract

Our study reveals that GBA harbors malignant potential at both epithelial and immune microenvironmental levels. The expression of CCL20, CCL5, and PRDX1 may serve as molecular markers for stratifying high-risk GBA, while PRDX1 represents a promising therapeutic target for reprogramming the tumor immune microenvironment in GBC.

问 AI

Bookmark

View Full Paper

Cite This Study

Xia et al. (Fri,) studied this question.

synapsesocial.com/papers/6975b350feba4585c2d6ecf8 https://doi.org/https://doi.org/10.1097/js9.0000000000004916

问 AI

Bookmark

View Full Paper