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The research aims to understand the gene expression changes in the endometrium and decidua vital for implantation during the menstrual cycle.

January 25, 2026JCI InsightOpen Access

Single-cell mapping of human endometrium and decidua reveals epithelial and stromal contributions to fertility

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The research aims to understand the gene expression changes in the endometrium and decidua vital for implantation during the menstrual cycle.
Characterized gene expression with bulk and single-cell RNA sequencing
Analyzed the mid-secretory phase of the menstrual cycle
Identified the glandular epithelium receptivity module signature comprising 556 genes
Investigated stromal cell population dynamics, focusing on decidual and senescent subsets
Discovered significant transcriptional changes in secretory glandular epithelial cells during the implantation window
Validated the GERM signature as a key marker of endometrial receptivity in samples from women with impaired fertility
Identified shifts in stromal cells that contribute to implantation modulation

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Single-cell RNA sequencing reveals molecular changes in endometrium affecting fertility, indicating pathways crucial for implantation.

Burns et al. (2026) studied this question.

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