What question did this study set out to answer?

The study aims to evaluate how different doses of mobilization affect 28-day mortality in critically ill patients undergoing mechanical ventilation.

January 26, 2026American Journal of Respiratory and Critical Care Medicine

Impact of Mobilization Dose on Outcome of Critically Ill Patients Receiving Mechanical Ventilation—A target trial emulation using data from the TEAM trial

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The study aims to evaluate how different doses of mobilization affect 28-day mortality in critically ill patients undergoing mechanical ventilation.
Conducted a target trial emulation to estimate per-protocol effects.
Analyzed data from patients in the TEAM trial receiving invasive mechanical ventilation.
Assessed simulated interventions with varied mobilization durations and ICU mobility scale thresholds using g-formulas.
In 741 patients, prolonged mobilization at low mobility levels was linked to a higher risk of mortality (RR 1.33).
Achieving a mobility scale >4 on a day showed that prolonged mobilization didn't significantly increase mortality compared to natural course (RR 1.13).

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Implication

Target trial emulation reveals mobilization dosage impacts 28-day mortality in critically ill patients, suggesting increased caution in interventions.

Cite This Study

Neto et al. (2026) studied this question.

synapsesocial.com/papers/6977032e722626c4468e82e9 https://doi.org/10.1093/ajrccm/aamaf109

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Implication

Target trial emulation reveals mobilization dosage impacts 28-day mortality in critically ill patients, suggesting increased caution in interventions.

Impact of Mobilization Dose on Outcome of Critically Ill Patients Receiving Mechanical Ventilation—A target trial emulation using data from the TEAM trial

Key Points

Discussion

Implication

Cite This Study

Impact of Mobilization Dose on Outcome of Critically Ill Patients Receiving Mechanical Ventilation—A target trial emulation using data from the TEAM trial

Key Points

Discussion

Implication

Cite This Study

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