Fatigue in COPD: a Longitudinal, Multidimensional Perspective.

Physical activity was the only direct predictor of fatigue, while fatigue directly influenced dyspnea, dyspnea-related emotions, and health-related quality of life. This study highlights the important role of fatigue within a complex network of physical, psychological, health status, and behavioral factors. The complexity of the interrelatedness of these factors suggests that single-target interventions are unlikely to be effective. Rather, integrated interventions, such as pulmonary rehabilitation, are needed.