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January 26, 2026European Journal of EpidemiologyOpen Access

Lifestyle factors and all-cause mortality in long-term cancer survivors: a population-based prospective cohort study

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Authors

CZChunsu ZhuMTMelissa S. Y. ThongDDDaniela Doege

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Overview

A prospective cohort study investigates lifestyle factors impacting mortality in long-term cancer survivors, suggesting lifestyle changes can improve outcomes.

Key Points

  • This study investigates how individual and combined healthy lifestyle factors relate to all-cause mortality in long-term cancer survivors.
  • Analyzed data from 6,057 participants with breast, colorectal, or prostate cancer in Germany.
  • Created a healthy lifestyle score based on alcohol consumption, BMI, physical activity, and smoking.
  • Used Cox proportional hazards regression to assess the relationship between lifestyle factors and mortality.
  • Followed participants for up to 12.3 years, recording 2,015 death events.
  • Participants in the middle and highest tertiles of the healthy lifestyle score had 27% and 32% lower mortality respectively compared to the lowest tertile.
  • A significant dose-response relationship was found (p-trend < 0.001).
  • Full adherence to smoking cessation, physical activity, and ideal BMI significantly reduced mortality risk.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6977032e722626c4468e838chttps://doi.org/10.1007/s10654-025-01350-6
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